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High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders

Authors: Momeni N, Brudin L, Behnia F, Nordstrom B, Yosefi-Oudarji A, Sivberg B, Joghataei M, Persson B

Year: 2012

Source: Autism Research and Treatment 2012:6 pages.

Abstract: Autism spectrum disorders (ASDs) are neurodevelopmental and behavioural syndromes affecting social orientation, behaviour, and communication that can be classified as developmental disorders. ASD is also associated with immune system abnormality. Immune system abnormalities may be caused partly by complement system factor I deficiency. Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b, which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of infections in humans. In this paper, we show that the mean level of factor I activity in the ASD group is significantly higher than in the control group of typically developed and healthy children, suggesting that high activity of complement factor I might have an impact on the development of ASD. Abstract originally from the Hindawi Publishing Corporation. Reprinted with permission under a Creative Commons Attribution license.

Institution: School of Natural Sciences, Linnaeus University, 39182 Kalmar

Language: English

Subject headings: Autism, Children

Geographic areas: Europe, Sweden


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